A loxP site was inserted upstream of exon 1 and an FRT flanked puro cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Cre-mediated recombination in the germline resulted in the deletion of exons 1 and 2 and the puromycin selection cassette. (J:213776)
Basic Information
(C57BL/6 x 129S4/SvJae)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count