CRISPR/Cas9 technology replaced the last 55 nucleotides of the mouse Arhgap11a exon 5 starting at the position where in human ARHGAP11B, the C to G point mutation generates a new splice-donor site, with 141 nucleotides encoding the human ARHGAP11B-specific 47 amino acid sequence followed by three further nucleotides (TAG) to generate a translational stop codon. (J:308527)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Endonuclease-mediated
Insertion, Intragenic deletion
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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