The targeting construct inserted upstream of exon 1 a loxP site and downstream of exon 2 an FRT-flanked neomycin resistance cassette with a 3' loxP site. Flp-mediated recombination removed the section cassette and leave exons 2 and 3 floxed. (J:326793)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count