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Guide RNAs (AGCTGGTGAAGAAAGAACCG and CAAGTCAGCTCCAGCTGCCT) are designed to create a CCG to TTG missense mutation resulting in a proline to leucine mutation (P461L) orthologous to the location of human SNP rs202178565 in the Eph receptor A1 (Epha1) gene. Human SNP rs202178565 has been found in human EPHA1 and is associated with increased risk of sporadic Alzheimer's disease (AD). (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
