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CRISPR/Cas9 technology generated a valine to glycine (V721G; GTT to GGC) and leucine to glycine (L722G; CTG to GGC) substitutions at amino acids 721 and 722, respectively, in the PCD domain. These mutations correspond to the human V729G/L730G mutation that abolishes the PER2-CK1 association. (J:326603)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
