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Using CRISPR/Cas9 endonuclease-mediated genome editing, a donor plasmid designed to insert a codon improved cre recombinase (iCre) and a polyadenylation sequence immediately downstream of the start codon of the prolactin family 8, subfamily a, member 2 (Prl8a2) gene, a single guide RNA (ACTAGCAGTCTTATCCAACCNGG), and the cas9 nuclease with a puromycin resistance sequence were transfected into G4 embryonic stem (ES) cells. (J:326357)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
