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CRISPR-targeting inserted a CAG promoter, floxed STOP cassette, and human gene coding sequence with mutation that results in the amio acid substitution of threonine with methionine at position 790 (T790M) and leucine with arginine at position 858 (L858R). (J:293217)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
