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The targeting construct inserted into the locus a CAG promoter, floxed STOP cassette, ivermectin (IVM)-gated silencing receptor (IVMR) containing the human GLRA1 coding sequence with two amino acid substitutions (F207A and A288G), a 2A cleavage site, GFP, WPRE (the woodchuck hepatitis virus posttranscriptional regulatory element), polyadenylation sequence, and neomycin resistance cassette. This allele allows for inducible and reversible silencing neurons. (J:293217)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
