CRISPR/cas9 endonuclease-mediated genome editing was used to insert an in frame protein containing IRES-followed by F3-FRT-Cre-F3-FRT in reverse orientation into the 3' UTR of the gene. The cassette contained approximately 1 kb of 5' and 5' flanking homology arm sequence. Expression of Flpo recombinase recombines cre to the correct orientation. (J:325967)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6 x SJL
Endonuclease-mediated
Insertion
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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