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CRISPR/Cas9 technology was used to delete exons 2-5 of the mouse Serpina3c gene by non-homologous recombination. qPCR analysis demonstrated that mRNA expression was abolished in multiple tissues, including brown adipose tissue (BAT), inguinal and epididymal white adipose tissue (WAT), liver, and muscle. Western blot analysis confirmed the absence of protein expression in the inguinal and epididymal WAT of homozygous mutant mice. (J:238766)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
