The targeting construct inserted upstream of exon 1 an F3-flanked puromycin resistance cassette with a 5 prime loxP site and downstream, of exon 2 an FRT-flanked neomycin resistance cassette with a 3 prime loxP site. Flp-mediated removed the selection cassettes and left exons 1 and 2 floxed. (J:325407)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count