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The targeting vector is designed to insert the ABE (Adenine Base Editor) reporter construct into the Gt(ROSA)26Sor locus containing a CAG promoter, mutated Venus*, bovine hGH, and polyA sequence. Venus* is a non-functional reporter that has codon 81 mutated into a stop codon. When an ABE together with a guide RNA that binds at the mutant site is introduced into cells, the stop is converted into a glutamine codon and the reporter will express GFP. (J:94077)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
