A loxP site and FRT-flanked puromycin selection cassette was inserted into Not! site of exon 1 and a second loxP site downstream of exon 1. Flp-mediated recombination removed the selection cassette and left exon 1 floxed. (J:325253)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count