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The cDNA of Uprt from Toxoplasma gondii (T. gondii) was inserted into a Rosa26 targeting vector. A knockin vector was created with Uprt cDNA flanked by a floxed-stop cassette. Uprt-knockin mice were generated by standard homologous recombination in mouse embryonic stem (ES) cells. The presence of transcriptional stop cassette PGK-neo-pA-3xpA prevented downstream Uprt cDNA expression, while mating with mice expressing tissue/cell-specific Cre activated the expression of Uprt cDNA in a cell-specific manner. (J:324326)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
