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Guide RNA and a mutant ssDNA oligonucleotide template are designed to create a CGT to a GAG mutation, resulting in an arginine to glutamic acid substitution at position 46 (R46E) in the insulin B chain (B22) of the insulin II (Ins2) gene [R(B22)E]. A silent mutation was also added, creating an Alu I restriction site. (J:324187)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
