Exon 6 sequences were flanked by two loxP sites and an frt-flanked neomycin selection cassette. The FRT-neo-FRT sequence was removed via FLP-mediated recombination and exon 6 was removed via Cre-mediated recombination in the germline. (J:273327)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count