Exons 1316 (encoding the PDZ domain) of the gene were flanked with loxP sites and an frt-flanked neomycin selection cassette. The neomycin selection cassette was removed in the germline via FLP1-mediated recombination. (J:285373)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count