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CRISPR/cas9 mediated recombination using a single-stranded donor RNA with 2 GCC mutations was used to insert a W197A mutation. The second set of targeted nucleotides did not insert in this allele. This allele was created in embryos from mice homozygous for Ifih1tm1Aki. This mutation reduces RNA editing activity. (J:323650)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
