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This transgene expresses a Tcrb clone specific for the M38-derived epitope of MCMV. The "Mini" mouse is transgenic for the rearranged hybridoma Tcrb chain only, which was expressed by nearly 100% of the CD8 T cells, while the Tcra chain is of endogenous origin. This increases the percentage of nave M38-specific CD8 T cells from undetectable levels in C57BL/6 mice to 10% of the total. (J:183174)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
