The targeting construct inserted a loxP upstream of exon 4 and an FRT-flanked puromycin resistance cassette with a 3' loxP site downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exon 4 floxed. (J:323095)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count