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A loxP site, a neomycin resistance gene cassette, and a second loxP site, were inserted 5' to exon 5, and a third loxP site was inserted 3' to exon 5. Exon 5 encodes the end of the second transmembrane domain (TM2) and a portion of the intracellular loop between TM2TM3. Deletion of this exon results in a preterm stop codon and complete KCC2 knockout. The neomycin cassette was removed via Cre-mediated recombination in the germline of mice, leaving loxP sites flanking exon 5. (J:292640)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
