The targeting construct contains a loxP site upstream of exon 2 and a second loxP site downstream of exon 2. The construct also includes an FRT-flanked neomycin cassette, which is removed with a self-excising flp recombinase included in the construct. (J:292951)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count