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Zygotes carrying the Casp8em1Gne allele (p.D225A and p.D218A and Casp8tm1.1Gne allele p.D387A) were targeted with sgRNAs (targeting AGAGATGAGCCTCAAAATGG) and an ssODN template (AAACAGGAACACCAATGCAAAGAGAGAGGTAGGAGACACACCTACCCGTGACTCACTAGCTTGTTCTCTTGGCGAGGCACAGAGCTCCGCCATCTTCAGGCTCATCTCTGCAAGCAACCAAAAAAACGTCACACTTAGGACAACCTAAGGACC) template using CRISPR/Cas9 technology to change aspartic acid codon 212 (GAC) in exon 8 to alanine (GCC) (p.D212A). (J:281456)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
