A loxP site was inserted upstream of the first exon and an FRT flanked neo cassette and loxP site were inserted downstream of the second exon via homologous recombination. Flp mediated recombination removed the neo cassette. (J:322144)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count