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EN
A cassette containing a neomycin resistance gene, flanked by LoxP sites, was inserted downstream of exon 11. The T287A mutation was introduced by site directed mutagenesis, thereby also introducing a TspRI restriction site. The neomycin cassette was subsequently deleted of the targeted ES clones by transient transfection with a flp recombinase. (J:251803)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
