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EN
CRISPR/Cas9 endonuclease-mediated genome editing is used to create amino acid substitutions at positions 461 (lysine to glutamine, K461Q, AAA to CAA), 478 (lysine to glutamine, K478Q, AAG to CAG), and 489 (arginine to glutamine, R489Q, CGG to CAG) located in the activation function 1 (AF1) domain. (J:326815)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
