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To mimic a mutation associated with hereditary pancreatitis in human (p.K23R), lysine codon 24 (AAA) in exon 2 was mutated to an arginine codon (AGA) (c.71A>G, p.K24R). A loxP site flanked neomycin resistance gene cassette was inserted into intron 1 and removed through subsequent cre-mediated recombination. (J:320409)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
