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CRISPR-targeting introduced a C to G point mutation (c.1783C to G) encoding the amino acid substitution of histidine with aspartic acid at position 595 (H595D) and two silent mutations (c.1788C to A (I596I) and c.1791T to C (Y597Y)) to avoid re-cleavage by Cas9. (J:318756)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
