The targeting construct introduced a loxP- and FRT-flanked neomycin resistance cassette into intron 7 and a single loxP site upstream of exon 6. Flp-mediated recombination removed the selection cassette and left exon 6 floxed. (J:319442)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count