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EN
The targeting construct is designed to insert an adenosine to thymidine point mutation, resulting in a tyrosine to phenylalanine substitution at position 876 (Y876F). A loxP-flanked neomycin (neo) resistance cassette, in opposite orientation to the gene, is placed upstream of the mutated exon. Germ line, cre mediated recombination removed the neo cassette. (J:285753)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
