The targeting construct inserted upstream of exon 3 an FRT-flanked neomycin resistance cassette with a a 3' loxP site and downstream of exon 5 a loxP site. Flp-mediated recombination removed the selection cassette and left exons 3 through 5 floxed. (J:318724)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count