The targeting construct inserted upstream of Mir222 a loxP site and downstream of Mir221 an FRT-flanked neomycin resistance cassette with a 3 prime loxP site. Flp-mediated recombination removed the selection cassette and left the microRNAs flanked. (J:318753)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count