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The CAG-a loxP site flanked neo-Westphal stop-FLAG-mouse Foxo1* cassette followed by an FRT site-framed IRESeGFP expression cassette were inserted into ROSA26 locus via homologous recombination in the ES cells. The Foxo1 cDNA with deleted transactivation domain acting as dominant-negative Foxo1 transcripts. In presence of cre recombinase, a loxP site flanked neo-Westphal stop sequence is removed to allow expression of mutated Foxo1 gene driven by CAG promoter. (J:301891)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
