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The CAG-a loxP site flanked neo-Westphal stop-FLAG-mouse Irs2 cassette followed by an FRT site-framed IRESeGFP expression cassette were inserted into ROSA26 locus via homologous recombination in the ES cells. In presence of cre recombinase, a loxP site flanked neo-Westphal stop sequence is removed to allow expression of FLG epitope-tagged mouse Irs2 driven by CAG promoter. Expression of flp recombinase removes FRT site-framed IRESeGFP. (J:318815)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
