A rox-flanked STOP, herpesvirus internal ribosomal entry site followed by a Cre recombinase was integrated into the endogenous Lgals3 locus after the stop codon in exon 6. A rox-flanked-STOP inserted before the IRES can be removed by dre recombinase allowing the expression cre recombinase from endogenous Lgals3 promoter. (J:318676)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count