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Using CRISPR/Cas9 technology, a 27,282-bp central segment of the human BCL2L11 gene flanked by 12,773- and 26,632-bp homology arms (consisting of the proximal and distal regions of the mouse Bcl2l11 gene), respectively including a conditionally removable loxP-flaked-segment (2.9-kbp) of intron 2, a cryptic human exon immediately 3 of this, and a native human exon some 20 kbp downstream replaced the mouse Bcl2l11 locus. (J:318662)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
