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Inversion of the H19 ICR sequence was induced at the mouse endogenous locus by CRISPR/Cas9 genome editing. Three lines carried correctly inverted ICR alleles; two of those three carried the artificial enzyme site. This is a mutant mouse line 21 established from these two F0 mice (lines 21 and 23). (J:317705)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
