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A loxP-flanked Neo-3x-stop cassette, murine Il7r containing the B-cell acute lymphoblastic leukemia (B-ALL)-associated activating P243insPPCL mutation, and a self-cleaving T2A-linked GFP reporter were inserted into the locus. The P243insPPCL mutation is an in-frame insertion of four amino acids; proline, proline, cysteine, and leucine at the position 243 proline. (J:317339)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
