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The transgene encodes the disease-associated P301S mutation and includes four microtubule-binding domains and one N-terminal insert (1N4R). The PSKQ (PS19KQ) mice were generated at the UNC animal core facility by incorporating a single acetylation-mimicking mutation in the tau transgene at residue K280 (K280Q). Three founder lines (referred to as PS-KQ lines 6, 12 and 13) were generated. (J:94077)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
