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The transgene contains a portion of human BAC clone (CTD-2149o15, Invitrogen) including the entire APOA1 gene as well as 6.3 and 3.7 kb of 5' and 3'-flanking regions, respectively. Site-directed mutagenesis altered all four tryptophan residues to phenylalanine resulting in the 4WF isoform. (J:304480)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
