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Exons 5 to 10 were flanked by loxP sites. An FRT-flanked puromycin selection cassette was inserted downstream of exon 10 before the second loxP site. Flp-mediated recombination removed the selection cassette. Exons 5-10 were deleted via cre-mediated recombination in the germline. Deleting these exons deletes the cystathionine beta-synthase (CBS) 2 domain and parts of the CBS1 and 3 domains and is predicted to generate a frame shift from exon 4 to exon 11 and premature stop codon in exon 12. (J:317473)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
