Exons 5 to 10 were flanked by loxP sites. An FRT-flanked puromycin selection cassette was inserted downstream of exon 10 before the second loxP site. Flp-mediated recombination removed the selection cassette. (J:317473)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count