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A 3.5 Kb fragment from a plasmid carrying a rat insulin Ins2-tTA cassette and a 3.9 Kb fragment from a plasmid carrying TetO7 cloned upstream of Cre-encoding DNA were co-injected into fertilized oocytes to produce double-transgenic mice. Five lines were generated and one line showed cre activity doxycycline dependant manner, on with the absence and off with the presence of doxycycline, in islet cells. (J:244123)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
