The targeting construct contains a loxP site and an FRT-flanked neomycin cassette upstream of exon 1 and a second loxP site downstream of exon 2. Flp-mediated recombination removed the neomycin cassette. (J:101977)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count