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CRISPR/cas9 meditated recombination inserted a cassette containing a modified human ACE2 cDNA, loxP site, woodchuck hepatitis virus post-transcriptional regulatory element, simian virus 40 polyA sequence, loxP site, and an FRT-flanked PGK-neo and loxP site directly after the ATG site in exon 2. The human ACE2 cDNA was modified to use the mouse Ace2 signal peptide and codon-optimized for a mouse. (J:315719)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
