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The targeting construct inserted upstream of exon 7 a floxed wild-type mini gene encoding exons 7 through 18 and the 3 UTR, and an FRT-flanked neomycin resistance cassette. Exon 8 was modified to encode the amino acid substitution of aspartic acid to alanine at position 273 (D273A). (J:316669)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
