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The targeting construct inserted a loxP site upstream of exon 2 and an FRT site, loxP site, 2A sequence, and a truncated (nonfunctional) NGFR reporter gene for cre-mediated deletion downstream of exon 5. FLP-mediated recombination removed the selection cassette inserted downstream of exon 5. NGFR expression is minimal even upon cre-mediated recombination thus cannot be used as intended. (J:313420)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
