The targeting construct inserted a loxP and an F3 site upstream of exon 3 and an FRT site and loxP site downstream of exon 3. Flp-mediated recombination removed the selection cassettes and left exon 5 floxed. (J:288489)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count