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EN
CRISPR/cas9 genome editing is used to create an amino acid substitution at position 619 (arginine to tryptophan, CGG to TGG, R619W) in exon 14 and a silent mutation (CTC to CTT) introduced at amino acid position 616 to create a BspE1 restriction site. (J:341570)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
