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An open reading frame corresponding to amino acids 1-520 of the mouse Neurl1a gene (Genbank: BC099702) is fused to a Flag tag epitope and subsequently cloned into tetO plasmid pMM400. An SV40 polyadenylation (polyA) site in the plasmid was replaced with a human growth hormone (HGH) polyA site. This is a dominant-negative form of Neurl1a that lacks its RING Zn finger, the domain that possesses the ubiquitin ligase activity. (J:178916)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
